Detailed view for Wbm0624

Basic information

TDR Targets ID: 232633
Wolbachia endosymbiont of Brugia malayi, NADH:ubiquinone oxidoreductase chain K
Source Database / ID:  GenBank

pI: 6.7121 | Length (AA): 102 | MW (Da): 11230 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 3

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00420   NADH-ubiquinone/plastoquinone oxidoreductase chain 4L

Gene Ontology

Mouse over links to read term descriptions.
GO:0016651   oxidoreductase activity, acting on NADH or NADPH  
GO:0055114   oxidation reduction  
GO:0042773   ATP synthesis coupled electron transport  

Structural information

Modbase 3D models:

No model available for this protein in Modbase.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_130712)

Species Accession Gene Product
Arabidopsis thaliana ArthCp076   NADH dehydrogenase subunit 4L
Arabidopsis thaliana ArthMp058   NADH dehydrogenase subunit 4L
Candida albicans CaalfMp12   NADH dehydrogenase subunit 4L
Dictyostelium discoideum DidioMp41   NADH dehydrogenase subunit 4L
Escherichia coli b2279   NADH:ubiquinone oxidoreductase, membrane subunit K
Mycobacterium tuberculosis Rv3155   Probable NADH dehydrogenase I (chain K) NuoK (NADH-ubiquinone oxidoreductase chain K)
Mycobacterium ulcerans MUL_2469   NADH dehydrogenase subunit K
Oryza sativa 3131399   NADH dehydrogenase subunit 4L
Oryza sativa 6450148   NADH dehydrogenase subunit 4L
Wolbachia endosymbiont of Brugia malayi Wbm0624   NADH:ubiquinone oxidoreductase chain K

Essentiality

Wbm0624 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
mtu3207 Mycobacterium tuberculosis non-essential nmpdr
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model
No druggable targets predicted through repurposing network model

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier Wbm0624 (Wolbachia endosymbiont of Brugia malayi), NADH:ubiquinone oxidoreductase chain K
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